Targeting Lymphotoxin β Receptor with Tumor-Specific T Lymphocytes for Tumor Regression

Cytotoxic T lymphocytes specific for self tumor immunoglobulin express T cell receptor delta chain

CTL are thought to play a role in the elimination of transformed cells in vivo. The effectiveness of such CTL is in part dependent on recognition of tumor specific antigens. Among the best characterized tumor-specific antigens are the unique or idiotypic determinants on the Ig of B cell lymphomas. Here we describe the generation and properties of human CTL specific for the idiotype on autologou...

Tumor-Specific Cytolytic T Lymphocytes for Local Costimulation Reinvigorates

Targeting the tumor vasculature with TEM8-specific T cells

Background T cell immunotherapy with genetically modified T cells expressing chimeric antigen receptors (CARs) has shown promise in preclinical models as well as early clinical studies. However, patients with solid tumors often do not respond as well as patients with hematological malignancies. This lack of efficacy for solid tumors is most likely due to several factors including a) emergence o...

Tumor Eradication by Wild-type p53-specific Cytotoxic T Lymphocytes

The tumor suppressor protein p53 is overexpressed in close to 50% of all human malignancies. The p53 protein is therefore an attractive target for immunotherapy. Cytotoxic T lymphocytes (CTLs) recognizing a murine wild-type p53 peptide, presented by the major histocompatibility complex class I molecule H-2Kb, were generated by immunizing p53 gene deficient (p53 -/-) C57BL/6 mice with syngeneic ...

Molecular Imaging in Tracking Tumor-Specific Cytotoxic T Lymphocytes (CTLs)

Despite the remarkable progress of adoptive T cell therapy in cancer treatment, there remains an urgent need for the noninvasive tracking of the transfused T cells in patients to determine their biodistribution, viability, and functionality. With emerging molecular imaging technologies and cell-labeling methods, noninvasive in vivo cell tracking is experiencing impressive progress toward reveal...